DALEL Exhaustive search for linear information in proteins



We applied DALEL to explore the linear information encoded in the SH3 domain recognition peptides in the budding yeast Saccharomyces cerevisiae. We succeeded, using only the linear information to independently identify the majority of experimentally determined recognition peptides. We discovered, however, a number of peptides with distinct properties that may serve ancillary roles. The strategy could be applied to any recognition domain for constructing both empirical and quantitative models of biochemical networks.